Build the science that shapes the future of human health.
Application closing date: June 21st, 2026

Join a place where ambitious science thrives
Human Technopole (Milan) is a rapidly expanding life science institute where international researchers and cutting-edge technologies converge to accelerate biomedical discovery. Our mission is to transform bold scientific ideas into advances that improve human health.

Within this mission, the Casañal Group combines cryo-electron microscopy, biochemistry, biophysics, and structural proteomics to dissect the molecular machineries of RNA modification, a rapidly expanding and biomedically important layer of gene regulation whose dysregulation drives cancer, neurodevelopmental disorders, and viral infection. We focus on the human m6A and m5C writer complexes, their crosstalk with other gene expression machineries, and the translation of our atomic-resolution insights into therapeutic opportunities.

We are seeking an ambitious, highly motivated Postdoc with a strong interest in the structural and functional characterisation of m6A and m5C writers and erasers, and their multi-subunit assemblies on RNA and chromatin, using integrative approaches. Previous expertise in structural biology, RNA biology, and/or biochemistry of multi-protein complexes is essential. We encourage international candidates to apply and will support applications to external Postdoctoral fellowship schemes (EMBO, Marie Curie, HFSP, etc.).

Your mission

• Conduct research, develop innovative methods and tools, and ensure accurate documentation of activities.
• Generate high-quality data, maintain proper records, and contribute to writing scientific manuscripts.
• Publish results and present findings at conferences, seminars, and workshops.
• Train and support students and junior staff, while collaborating with internal and external researchers.
• Plan and manage experiments and data analysis in line with the research group’s objectives.

Grow your skills
Postdoctoral researchers engage in cutting-edge research in the life sciences, collaborating with interdisciplinary teams and utilizing advanced technologies to contribute to impactful scientific publications. They support the advancement of existing research and contributing to the evaluation and establishment of new research directions

Human Technopole supports career development through training, mentoring and dedicated learning opportunities.

What you'll bring

Essential - All requested qualifications and requirements must be fully met by the closing date of the call and must be clearly verifiable through the candidate’s CV and supporting documentation. 

• Ph.D. in a relevant field.
• Research background with a track record of peer-reviewed publications in the field of RNA biology, structural biology and/or biochemistry of multi-protein complexes.
• Expertise in experimental design and implementation.
• Ability to develop and implement robust research projects, including formulating hypotheses, designing experiments, and optimizing protocols.
• Competence in acquiring, handling, and analyzing large and complex datasets, ensuring data quality, reproducibility, and appropriate interpretation.
• Ability to evaluate research findings, troubleshoot technical issues, and draw meaningful conclusions.
• Ability to write publications, present findings, and effectively communicate research to diverse audiences, including peers, funders, and the public.

Organisational and social skills

• Strong problem-solving and organizational abilities.
• Teamwork and good communication skills.
• Networking and public speaking proficiency.

At HT, your discoveries contribute to a global effort to improve human health.

Why Human Technopole
HT offers an international and dynamic workplace, competitive welfare provisions, flexible working policies and relocation support. Researchers moving to Italy may benefit from attractive tax benefits. We promote work–life balance and provide parental support initiatives.

How to apply
Submit:
• CV
• Motivation letter (English)
• Contact details of two referees

This is a 4-year contract offered under CCNL Chimico Farmaceutico, Level B2

Salary: up to € 43.000,00 depending on the candidate’ seniority.
The position is based in Milan, Italy, within our vibrant international campus.
We strongly encourage applications from candidates belonging to protected categories (L. 68/99).